Pietsch is on his way back home to Australia after hurting himself in the Wallabies' 42-37 tour-opening triumph over England at Twickenham on Sunday morning.
The Western Force recruit's disappointment is joy for Queensland Reds and Australia XV vice-captain Josh Flook, who will join the squad after impressing in a 10-10 draw with Bristol on the weekend.
"Dylan Pietsch picked up a calf injury against England and will return to Australia to begin his recovery," said a Wallabies team statement on social media.
"Josh Flook will join the squad in Cardiff."
With skipper Harry Wilson also out of Monday's clash with Wales due to concussion protocols, coach Joe Schmidt will need to make changes in the back row and backline.
Pietsch's exit will likely mean a promotion for Max Jorgensen, who scored the last-gasp match winner against England, with Samu Kerevi, Harry Potter and Flook in contention to join the bench.
The match-winner called from around the world 🗣— Wallabies (@wallabies) #Wallabies pic.twitter.com/ySiTbWUO0VNovember 11, 2024
Veteran Kerevi would be making his appearance since last year's ill-fated World Cup while English-born Potter would become the 18th debutant under Schmidt.After starting on the bench at Twickenham, Langi Gleeson looms as a like-for-like No.8 replacement for Wilson.
Schmidt, though, also has the option of moving dual John Eales Medallist Rob Valetini to the back of the scrum and Jeremy Williams from the second row to No.6 and calling on 2023 World Cup captain Will Skelton or Lukhan Salakaia-Loto to start at lock.
The Wallabies must continue Wales' winless run this year to keep alive their hopes of a first grand slam sweep of the British Isles since 1984.
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